If your outlets are smaller than your inlets - it is possible that even when you need max bypass, you still won't be able to get the pressure out. Always have you out be able to flow more than the in.
My philosophy is to always have the returns, bypasses, etc always bigger than the inlet, that way the regulator / bypass valve / etc can be set and it will work under all conditions.
At a minimum a -10 would work becuase you will never have 100% flow through the bypass ( I wouldn't go any smaller than a -10 for my system).
I'm sure others will have opinions.