If you have a cam that idles around 1000 and up, you don't make power until the distributor is fully advanced anyway, so it makes sense to lock it in. The disti will start advancing on its own at idle, and you need it locked.
If you idle below 1000, then you can gain more power by having a curve.
On my cams that are 250 deg and below @ .050, I run timing, above, locked.
Your mileage may vary.