Depends on what you're doing and how much your time and effort is worth.
Anything much over 7000 rpm and about 750hp aspirated is really when you should consider stepping up. I mean you can get away with more... blown for sure... and smaller nitrous shots... but then you still have a part that's been out in the world going through God knows what for 20... 30... 40 years. I mean I have ran them on no bullshit, dyno'ed 730hp engines, added a 250 shot of nitrous, and let her rip to 7300 and gone seasons, but I would never say that is the norm... and a decent set of rods won't set you back much more than a couple hundred over the cost of labor and parts on your old rods.