In my uneducated opinion, the mod motor would be way cool. I know there making lots of power out of those things and big turbos.
If it was me though, I would start with the 460 you already have. Get a new set of heads (bigger chambers), add a pair of turbos, and run the E85. If you stick to that 800hp goal, and build it right, a pressurized 460 will last forever at that hp.