Which 6-71 are you talking about? There are two different GMC 6-71's, a large and a small case, not to mention, several aftermarket cases and rotors.
Have the rotors been "stripped"? This means that the tips of the rotors have been machined for seals to tighten the clearance between the rotors and the case. A "stripped" blower will have less internal leakage and generate more heat.
What drive ratio will this setup include, or are you on your own for the drive?
If you can resist temptation and keep the boost to a reasonable amount, there is no reason you couldn't successfully run a blower. As long as you keep it out of detonation, the greatest loads on the pistons and rods will be at TDC on the intake stroke.
Lastly, your engine needs to be in sound condition before you undertake such an endeavour.
A couple things that might scare you away. 1.) It takes a lot of power to drive a blower. The crankshaft should be double-keyed and you don't want to run a cast hub damper. 2.) I would consider opening the ring gap to compensate for the addition heat and expansion.
Good luck,
Joe