I got an 02 5.3 with tuner, exhaust and intake. None really made a huge difference except for the trans adjustments... It sounds like its doing a whole lot more though. On my 7.3 Ford I did exhaust, intake, added an intercooler, aftermarket turbo and a TS flip chip and came close to doubling horsepower and torque while sacrificing very little on dependability. I won't touch the 2011 5.3 they run fine out the box. Does the 08 4.8 have the 4L60E trans or the six speed auto?
In the 02, that is one thing I like about the Hypertech programmer. You can adjust shift points and firmness and helps to make up for the lack of gears. As far as the engine tuning options go, just makes it ping and detonate.. sounds like pennies shaken in and empty Coors can, even if you run 91.
I'm just rambling now, supercharge and plan on buying a trans out of warranty if ya wants power.