You can. But unless you have already have a head unit installed, running it straight to the amp or through a eq will allow you to keep your dash untouched. Also a head unit doesn't put out a lot of power, 17 watts is about the highest (I know the box says a million). Under powered speakers blow much faster than speakers that have ample wattage due to distortion. What kind of speakers were you planning on running? Look at the RMS wattage of the speakers not the peak and match that to a amp again to the RMS per Channel or the other way around. Polk db series is what I run they are marine grade and the 6 1/2 are not too pricey. Just my two cents.
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