I have a '04 Chevy 2500 crewcab 4x4 6.0, it kills me running around town/stop and go 8 mpg's, maybe 11-13 pulling the boat, open freeway 14. i know 4x4 uses more but i didn't buy it for the mileage. if your're worried about mpg's and want to get the most than go diesel(more torque too).
btw it was my daily driver that's way i went gas, the wife got a new commuter car last year and now my daily driver is her old '03 tahoe - avg 15-17 during a weeks driving to work and errands. i switch weekly between the two trucks - after a week a driving the soccer mom suv i have to get back into my truck!!